Sickle cell trait diagnosis: clinical and social implications

Sickle-cell trait: novel clinical significance.

There is a long-standing controversy in the literature as to whether sickle-cell trait (SCT) should be viewed as a benign carrier state or as an intermediate disease phenotype. Because SCT is routinely detected by neonatal screening for sickle-cell disease, it becomes imperative that consensus on this issue be achieved in order to provide the best medical advice to affected individuals. The iss...

Sickle cell trait.

Sickle cell trait can pose a grave risk for some athletes. In the past few years, exertional sickling has killed nine athletes, including five college football players in training. Exercise-physiology research shows how and why sickle red cells can accumulate in the bloodstream during intense exercise bouts. Sickle cells can "logjam" blood vessels and lead to collapse from ischemic rhabdomyolys...

Sickle cell trait and frostbite.

Burkitt's lymphoma and sickle cell trait.

ONLY two areas of the world, tropical Africa and New Guinea, are endemic for Burkitt's lymphoma. These are the principal areas of the world where malaria still occurs in hyperand holo-endemic forms, and within these two areas the geographical distribution of the tumour coincides closely with that ofendemic malaria. These observations suggest the possibility of a causal connection between chroni...

Sickle cell trait and diabetic retinopathy.

The presence of sickle cell trait and the prevalence and severity of retinopathy were assessed in 124 Negro diabetics. Sickle cell trait had no adverse effect on diabetic retinopathy.